Kisspeptin 10mg

Novum BioScience Kisspeptin 10mg

Kisspeptin is a neuropeptide that plays a fundamental role in regulating the reproductive system by directly stimulating the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This action subsequently triggers the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which are essential for proper reproductive function.

The peptide works by binding to its receptor (GPR54) on GnRH neurons, effectively serving as the master switch that activates the entire reproductive hormone cascade. Research has shown kisspeptin’s potential in treating various reproductive disorders, including hypogonadism and infertility, while also demonstrating effects on sexual behavior, emotional processing, and metabolic regulation.

Beyond its reproductive functions, kisspeptin has garnered attention for its role in inhibiting cancer metastasis, particularly in melanoma and breast cancer, earning it the name “metastin.” Studies suggest therapeutic applications may extend to treating reproductive disorders, certain cancers, and potentially metabolic conditions, with ongoing research exploring its full clinical potential.

Research and community protocols for Kisspeptin-10 typically utilize subcutaneous dosing ranges of 100–300 mcg daily, often cycled for 4–8 weeks to support hypothalamic-pituitary-gonadal (HPG) axis function. 

Standard Subcutaneous Protocols

• Starting Dose: 100 mcg once daily or every other day to assess individual response. 

• Standard Dose: 200–300 mcg once daily, commonly administered before bed to align with natural LH pulse timing. 

• Advanced/Research Dose: Up to 500 mcg daily or split into twice-daily injections for individuals with suboptimal response. 

• Cycle Duration: Typically 4–8 weeks on, followed by a 2–4 week off period to prevent desensitization. 

Clinical and Weight-Based Dosing

In clinical trials, dosing is often weight-dependent:

• Men: Intravenous boluses of 0.3–1.0 nmol/kg (approx.  300–1000 mcg) effectively stimulate LH and testosterone. 

• Women: Doses vary by menstrual phase, ranging from 0.24–10 mcg/kg IV for acute stimulation or 6.4 nmol/kg twice weekly for hypothalamic amenorrhea.